Recently, Yoshida et al. revealed that sIL-2Rα levels in sera are dependent on the infiltration of tumor-associated macrophages (TAM) into the TME; TAM-derived matrix metalloproteinase-9 plays a pivotal role in the cleavage of IL-2Rα on T-cells in extranodal DLBCL and follicular lymphoma42. The gene discussed is IL2RA; the disease is neoplasm.