In addition, although increased frequency of Th22 cells was associated with a poor response to chemotherapy in B-cell NHL, the frequency of Th22 cells was dissociated with plasma IL-22 levels because IL-22 is produced not only by Th22 cells but also various other types of cells, such as activated T-cells and NK cells44. Here, IL22 is linked to B-cell non-Hodgkin lymphoma.