That study also found benefits of reducing EphA4 in rodent models of ALS, including preserved spinal cord motor neurons, increased neuromuscular junction (NMJ) innervation, and improved survival with heterozygous EphA4 KO in the superoxide dismutase 1 (SOD1G93A) mouse model2. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.