In addition, since interleukins such as IL-1, IL-6, IL-8, IL-10, tumor necrosis factors, and IFNs secreted by tumor-infiltrating lymphocytes are able to stimulate tumor cell proliferation, protect tumor cells from apoptosis, or promote angiogenesis and metastasis, the molecular mechanisms of these diverse effects of cytokines on cancer development and chemoresistance still need to be elucidated. This evidence concerns the gene IL1A and neoplasm.