25 genes showed an expression change in the same direction (either under/overexpression) in AD versus aging including the cilia genes VPS4B, CCNA1, DYNLRB2, NPHP1, DNAH7 and the ciliary Shh regulator BBS5; ‘negative regulation of cell death’ was enriched in this group (p value = 1.59e−09). This evidence concerns the gene SHH and Alzheimer disease.