Moreover, although we proved reduced glycolysis level and up oxidative phosphorylation level in FoxO1-deficient macrophages (Figs. 4 and 5, and Supplementary Figs. S4 and S5), we need more further study on the in vivo effects of FoxO1 on the metabolic switch and the direct consequences for tumor growth. The gene discussed is FOXO1; the disease is neoplasm.