IL37 and metastatic neoplasm: Coryneform bacteria are classically defined by the presence of unique α-branched β-hydroxy fatty acids called mycolic acids42 (predicted biosynthesis pathways shown to be nearly abolished in both ADT and ADT + AA patients; Supplementary Fig. 8 and Supplementary Data 2 and 3) in their cell wall, which can evoke interleukin-23 signaling43—a key cytokine thought to contribute to tumorigenesis and progression to metastatic disease in the context of inflammation-related cancers44.