We validated BMP7 upregulation at the protein level in 344SQR and 344SQP tumors (Fig. 1g) and in samples from patients with NSCLC, mixed Mullerian carcinoma, and adrenocortical carcinoma that initially responded to and later progressed on pembrolizumab (NCT02444741) or ipilimumab (NCT02239900) using immunohistochemical staining. This evidence concerns the gene BMP7 and adrenal cortex carcinoma.