The p-tau T217 assay discriminated between AD and non-AD neurodegenerative disorders (cutoff 242 pg/mL, AUC 0.91 [95% CI 0.80, 0.96], with accuracy of 90%, with 78% PPV, 97% NPV, 88% specificity [95% CI 0.79, 0.98], and 93% sensitivity [95% CI 0.78, 0.99]) compared to p-tau T181 ELISA (figure 3B) (cutoff 52 pg/mL, AUC 0.94 [95% CI 0.84, 0.98], showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity [95% CI 0.44, 0.99], and 97% sensitivity [95% CI 0.89, 0.99]). The gene discussed is MAPT; the disease is Alzheimer disease.