Comparison of means showed that the assay significantly differentiated AD and nvPPA (p < 0.0001; Cohen d 1.433, 95% CI 0.758, 2.171), svPPA (p < 0.0001; Cohen d 1.469, 95% CI 0.714, 2.296), bvFTD (p < 0.0001; Cohen d 1.586, 95% CI 0.822, 2.426), PSP (p < 0.0001; Cohen d 1.745, 95% CI 1.105, 2.455), and CBD (p < 0.0001, Cohen d 1.452; 95% CI 0.79, 2.177). Here, OPN1MW is linked to Alzheimer disease.