In comparison, p-tau T181 ELISA (cutoff 60 pg/mL, AUC 0.98 [95% CI 0.91, 0.99]), currently considered one of the best biomarkers for AD, showed 98% sensitivity (95% CI 0.88,0.99) and 86% specificity (95% CI 0.76, 0.99) (figure 4B). Here, MAPT is linked to Alzheimer disease.