Notably, 15 patients with life-threatening COVID-19 and auto-Abs against IFN-α2 and/or IFN-ω also had auto-Abs against other cytokines [IFN-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-10, IL-12p70, IL-22, IL-17A, IL-17F, and/or tumor necrosis factor–β (TNFβ)], only three of which (IL-12p70, IL-22, and IL-6) were neutralizing (in four patients) (fig. The gene discussed is IFNA2; the disease is COVID-19.