The degree of protection offered by PT2567 intervention in this article may be attributed, to some extent, to the modulation of multiple PH associated target genes for glut1, cxcl12, apln, edn1, icam1, sele and ccnd1 in pulmonary tissues, although contributions from other known PAH targets including bmpr2 [26], il-6 [51], sox17 [52] and cav1 [53] across multiple tissues and other organs are most probable and cannot be ruled out. Here, APLN is linked to pulmonary arterial hypertension.