However, a series of studies observed no association between BRAF mutation and clinicopathological markers of poor prognosis.14, 15 An overview of literature indicates that the clinical data linking BRAF mutation and DTC outcomes are not very consistent, with many controversial results reported.14, 16, 17 Since, the prognostic significance of BRAF mutations remains a topic of debate with conflicting reports, in this study we aim to evaluate if the presence of BRAF mutation is a prognostic factor in patients with papillary thyroid carcinoma older than 45 years old. Here, BRAF is linked to thyroid gland papillary carcinoma.