There are several animal models of preeclampsia and pregnancy-induced hypertension that demonstrate evidence of renal injury including the reduced uterine perfusion pressure [28, 29], the Dahl S rat [30, 31], the N-nitro-l-arginine methyl ester [32], and the transgenic renin-angiotensin model of preeclampsia [33]. This evidence concerns the gene REN and hypertensive disorder.