On the other, however, most of the DGP (WNT5A, DVL1, DVL3 and ROR2 in Robinow syndrome, FAT4 and DCHS1 in van Maldergem syndrome and RAB23 in Carpenter syndrome) participate in the non-canonical Wnt signaling pathway and in the process of planar cell polarity, which are key regulators of embryonic development [26]. This evidence concerns the gene ROR2 and Cerebro-facio-articular syndrome.