Data in the literature regarding EFEMP1 expression in the tumor epithelium are also controversial: it was found downregulated in lung, nasopharyngeal, prostate, hepatocellular and glioma cancers, compared to normal tissue [40,41,42,43]; on the contrary, it acts as oncogene in cervical, pancreatic and ovarian cancers [44,45,46]. This evidence concerns the gene EFEMP1 and neoplasm.