The fact of GIST originating from ICC is exemplified by shared immune-phenotypical features such as the expression of V-Kit Hardy–Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) (CD117) [5,6], anoctamin 1 (ANO1/DOG1) [7] and ETV1 [8], which are currently used as diagnostic biomarkers for GIST. Here, ANO1 is linked to gastrointestinal stromal tumor.