LAP3 and viral infectious disease: Moreover, in the Picornaviridae family, enteroviruses produce a short protein that is important for viral infection from an ORF partially overlapping with the viral polyprotein region at the +2 frame [46,47], and Foot-and-Mouth Disease Virus produces two alternative forms of the L protein, a peptidase, which is initiated at two in-frame AUGs [48] in an IRES-dependent mechanism.