Both in non-neoplastic and in tumor tissues of LUAD and LUSC, CpG-sites targeted by beads located peripherally in the CpG-dense area of KEAP1 (which includes the GCI-1 island) showed lower methylation levels, than the beads located in the central position of KEAP1 gene, including the CGI-2 island; the only exception was cg25801292 (Figure 2). The gene discussed is KEAP1; the disease is neoplasm.