Alternatively, given that in our study no clear inverse correlation was observed between KEAP1 methylation and NFE2L2 transcription, the epigenetic silencing of KEAP1 could represent an alternative or synergic way for NRF2 modulation of chemoresistance in NSCLC mediated by the KRAS gene status. Here, KEAP1 is linked to non-small cell lung carcinoma.