Looking at the molecularly stratified NSCLC subpopulations, a strong positive correlation between KEAP1 hypermethylation, mRNA expression levels of NRF2, and many ARE-driven target genes was observed in the LUAD KRAS wild-type subpopulation, both for many CpGs located in the CGI-1 island and in those located in the gene body. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.