KEAP1 and obesity due to melanocortin 4 receptor deficiency: In another study, Zhang Y and colleagues investigated the effect of the Nrf2 pathway on high-fat diet-induced (39.7 kcal% fat) obesity among Nrf2-KO, WT, and Keap1-knockdown mice, which concluded that the genetic alteration of Nrf2 does not prevent diet-induced obesity in mice [88].