In addition, it is worth noting that ferritin has site-specific targeting potential, as it can be recognized and internalized by ferritin-binding receptors, such as the transferrin receptor 1 (TfR1) for H-ferritin (Figure 6A) and scavenger receptor class A member 5 (SCARA5) for L-ferritin, which are over-expressed in a variety of tumor cells, especially in liver cancer cells [120,121]. The gene discussed is TFRC; the disease is neoplasm.