CD8A and infection: For example, LCMV-specific CD8 bTRM can control LCMV intracranial (i.c.)re-infection in the absence of CD8 TCM and TEM [41]; in contrast, LCMV i.c. infection in naïve immunocompetent mice is lethal as a result of antiviral CD8 T cell-mediated immunopathology in the brain [56].