In the present study, we sought to isolate limonoids and investigate their potential anti-inflammatory response by measuring the levels of inflammatory mediators, such as IL-1β and IL-6, and the activation of TNF-α, in RAW 264.7 mouse macrophage cells, and the level of IL-8 in HT-29 human colon carcinoma cells. This evidence concerns the gene CXCL8 and colon carcinoma.