Caffeine also regulated PD-like pathology in α-synuclein-induced mice by modulating macroautophagy by improving the microtubule-associated protein LC-3, reducing the receptor protein sequestosome 1 (SQSTM1/p62) and chaperone-mediated autophagy (CMA), and by regulating the expression of LAMP2A [153]. This evidence concerns the gene SQSTM1 and Parkinson disease.