Furthermore, the expression of Ser437-pAKT, a key regulator of the PI3K/AKT pathway that is responsible for the survival and metastasis of PCa cells, was significantly increased for the PC-3M cells in the co-culture compared with that for the mono-cultured cells (p = 0.049, Figure 1e and Figure S1). The gene discussed is AKT1; the disease is posterior cortical atrophy.