This observation is consistent with our previous reported studies, in which the inhibition of PIP5K1α led to significantly reduced expression of VEGFR1 and VEGFR2 [25], suggesting that PIP5K1α may be functionally linked to the VEGF-receptor signaling axis by mediating interactions between PCa cells and bone marrow cells. This evidence concerns the gene PIP5K1A and posterior cortical atrophy.