Transfer of purified CD8 T cells isolated from the cervical lymph nodes of NOD mice into NOD-severe combined immunodeficiency recipients resulted in inflammation of the LGs, but was not sufficient to cause inflammation of the SGs as observed in the study by Barr et al., demonstrating that CD8 T cells have a pathogenic role in LG autoimmunity [177]. Here, CD8A is linked to severe combined immunodeficiency.