The levels of ASP correlated significantly with HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) in a group of patients with non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) [30], when oxidative stress is an increasingly important determining factor for the local tissue environment [31]. Here, C3 is linked to metabolic dysfunction-associated steatohepatitis.