Of them, five genes (AXIN1, CTBP2 (C-terminal-binding protein 2), LRP5 (low-density lipoprotein receptor-related protein 5), MMP7 (matrix metalloproteinase 7), MAPK9 (mitogen-activated protein kinase 9) were downregulated while the expression of three genes (F2D7 (Frizzled 7), WNT7A, and 16) was enhanced by diabetes. The gene discussed is LRP5; the disease is diabetes mellitus.