Apart from promoting tumor growth via upregulation of a gene battery largely overlapping with that of Wnt signaling (Table 2), our data suggest that coordinated activation of the Hippo and PI3k/Akt pathways in T2DM might lead to exuberant extracellular matrix production and fibrosis in colorectal malignancies. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.