Although we did not find these genes differentially expressed in our samples, the modulation of two alternative Wnt ligand isoforms (WNT7A and 16) and the LRP6 isoform LRP5 as well as a number of auxiliary members of the canonical Wnt pathway provides convincing evidence that the CRC-promoting effect of insulin resistance might at least partly be mediated by heightened Wnt signaling. The gene discussed is LRP6; the disease is colorectal carcinoma.