Following its nuclear translocation, β-catenin interacts with TCF7L2 (transcription factor 7-like 2) and transactivates several target genes including miRNA-21 [11], the long non-coding RNA KCNQ1OT1 (KCNQ1 overlapping transcript 1) [12], and Gremlin [13], factors well known to promote the proliferation, local invasion, and metastasis formation of CRC cells. This evidence concerns the gene TCF7L2 and colorectal carcinoma.