Interestingly, five glycoproteins, namely AZGP1, ITH1, ITH2, SERPINC1 and SERPING2 were significantly expressed only in plasma samples of CRC patients with non-metastasis, while 11 glycoproteins consisting of A1BG, A2M, C2, CFB, CPN2, HP, ORM1, SERPINA1, SERPINA6, TTR, and VTN were significantly expressed only in the patients with metastasis. This evidence concerns the gene CPN2 and colorectal carcinoma.