CXCL8 and Familial prostate cancer: We observed the increased expression of CXCL8, CCL2, CXCL10, and CCL20 in prostate cancer tissues induced by intraprostatic injection of LNCaP cells stably transfected with SFMBT2 shRNA compared with prostate tissues injected with LNCaP cells stably transfected with control shRNA (Figure 1C).