HOXB13 and Familial prostate cancer: In addition, HoxB13, which is identified as a target gene of SFMBT2 transcriptional repressor [87], may contribute to NF-κB-mediated prostate cancer metastasis because over-expression of HoxB13 leads to reduced expression of IκBα and enhanced the nuclear translocation of NF-κB p65 in LNCaP cells [88].