Although M1 macrophages (classically activated) produce TNF-α, IFNγ, IL-12, and IL-23 and have pro-inflammation functions, M2 TAMs contribute to immune suppression, tumor growth, and metastasis via secretion of IL1β, IL-6, CXCL8, and VEGF [16,17,18,19]. This evidence concerns the gene CXCL8 and neoplasm.