Taking into account the well-known structure of the MDM2-p53 complex, and the fact that the inhibition of the wild-type (wt) p53 via p53/MDM2/MDMX axis is essential for cancer to develop (reviewed in [4]), inhibition of the MDM2-p53 and MDMX-p53 interactions has become a very promising strategy for cancer therapy and is described in more detail below. Here, TP53 is linked to cancer.