TP53 and neoplasm: In addition to inhibiting p53 and p73, ΔNp73 has other oncogenic functions such as binding to HIF1a and promoting its stability and tumor metastasis [72], driving chemoresistance by regulating the expression of the multi-drug resistance genes ABCB1 and 5 [73], interacting with TGFβ signaling by inducing its target genes PAI-1 and Col1a1 [74], or inhibiting PTEN tumor suppressor [75,76].