Several CDKN2A loss- or gain-of-function studies showed that this locus is involved in glucose homeostasis [86,87], β-cell functions (insulin secretion) and mass (proliferation) [88,89,90], gluconeogenesis [91], atherosclerosis [92,93,94,95], and hepatic steatosis [96]. Here, CDKN2A is linked to fatty liver disease.