In particular, decreased DNA methylation within the promoter of ANRIL (Antisens Noncoding RNA in the INK4 Locus), a 3.8 kb non-coding RNA transcribed from the genomic INK4b-ARF-INK4a locus, is associated with a higher risk for a child to develop obesity during adulthood [23]. The gene discussed is CDKN2A; the disease is obesity due to melanocortin 4 receptor deficiency.