Familial CPGLs occur as hereditary paraganglioma/pheochromocytoma (PGL/PCC) syndromes, including PGL1, PGL2, PGL3, PGL4, and PGL5, which are associated with germline mutations in the SDHD, SDHAF2, SDHC, SDHB, and SDHA genes, respectively [8]. Here, SDHD is linked to hereditary pheochromocytoma-paraganglioma.