These results indicate that disulfiram affects the regulation and/or balance of Th1 (MIP-2, RANTES, TNF, IFNγ and IL-1β), Th2 (IL-10) and protective Macrophage M1 (NOS2 or iNOS) responses to B. burgdorferi at day 21 and day 28 post infection. The gene discussed is IL1B; the disease is infection.