HCN4 and colorectal cancer: Statistical association between poor survival and hypermethylation of CGI was established in FIGN (p = 0.030), HTRA3 (p = 0.009), BDNF (p = 0.002), HCN4 (p = 0.018) and STAC2 (p = 0.007) and may be used as potential markers for metastasis progression in colorectal cancer (Figure 4; Table 1).