Only CGIs with a minimal methylation difference of >20% in primary tumour (% CGI primary tumour–% CGI NAT) or in both primary tumour and LMN (% CGI LNM–% CGI NAT) compared to NAT were used for further analysis, as a smaller methylation difference is unlikely to be of biological significance for gene regulation [23,24] (Table S5). Here, BRD2 is linked to neoplasm.