However, the role and underlying mechanisms of the ACE2/Ang1‐7/Mas axis in hypertensive nephropathy remain largely unclear, prompting us to investigate using a chronic Ang II infusion model of hypertension in ACE2 knockout (KO), Mas KO and, importantly, in ACE2/Mas double KO mice. The gene discussed is ACE2; the disease is hypertensive nephropathy.