ACE2 deficiency is associated with exaggerated kidney injury in mouse models of diabetes, Ang II‐induced hypertension and obstructive nephropathy,9, 10, 11, 12, 13 whereas treatment with human recombinant ACE2 (hrACE2) can slow the progression of diabetic and hypertensive kidney injury.14, 15. The gene discussed is AGT; the disease is Hypertension.