To test whether ACE2 distribution was affected by the presence of underlying diseases, we assessed the ACE2 localization pattern using tissues from subjects with chronic comorbidities (asthma, cardiovascular disease, chronic obstructive pulmonary disease, cystic fibrosis, diabetes, and smoking) and compared them to controls (Supplemental Table 2). The gene discussed is ACE2; the disease is chronic obstructive pulmonary disease.