Except for immune checkpoints, regulatory T cells (Treg) also regulate T cells activation and play a crucial role in immunologic escape mediated by multiple molecules including CTLA4, IL‐10, LAG3, CD73, and CD39, whereas CCL2 and CCL17 secreted by neutrophils recruit anti‐inflammatory macrophages and Treg to facilitate tumor growth.87, 88. This evidence concerns the gene CTLA4 and neoplasm.