C9 and amyotrophic lateral sclerosis: In addition to reducing intranuclear accumulation of C9ORF72‐S in RNA foci and normalizing dysregulated gene expression, ASOs were effective in reducing sequestration of the RBP adenosine deaminase RNA‐specific B2 (inactive) to the repeat expansion and in reversing glutamate toxicity in C9‐ALS patient fibroblasts and neurons (Donnelly et al., 2013).