Given these diverse interactions of TDP‐43 and FUS with lncRNAs it is likely that the cytoplasmic mis‐localization and perturbed functions of TDP‐43 and FUS in ALS MNs impacts on lncRNA distribution, expression and/or function that may contribute to MN degeneration and ALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.