TBK1 and Alzheimer disease: For example, TANK Binding Kinase 1 (TBK1) is a key gene regulating infection by multiple viruses, such as herpes simplex virus 1 (has 05168) and Epstein-Barr virus (hsa05169), and mutations in TBK1 activate the pathology of amyotrophic lateral sclerosis36 and early-onset Alzheimer’s disease.37