Several hypotheses have been proposed to explain this HDL-C concentration decrease such as the consumption of HDL particles, hemodilution, capillary leakage, decreased HDL synthesis by the liver (particularly in cases of associated liver dysfunction) or increased HDL clearance following the upregulation of scavenger receptor class B type 1 (SRB1) expression [20]. Here, SCARB1 is linked to Decreased liver function.