In the context of mood disorders, two single nucleotide polymorphisms (SNPs): the Val66Met (also designed as: rs6265, G196A; located in the pro-BDNF region) and BE5. 2 (located in a cis-regulatory region controlling the activity of a BDNF promoter) that reduce evoked release of BDNF (e.g. in the hippocampus) seems to be the most important [24–26]. This evidence concerns the gene BDNF and mood disorder.