IGF1 and infarction: In another study by Dobrucki et al., it has been demonstrated that angiogenesis in a rat model of infarction may not only be visualized by performing SPECT after the administration of a [99mTc]-labeled chelate-peptide conjugate containing an RGD motif; it has also been shown that the angiogenic response may be altered by the application of insulin-like growth factor-1 and then monitored using this imaging approach [31].