ARAP1, single nucleotide polymorphisms (rs1552224 and rs11603334) in which were confirmed to increase type 2 diabetes susceptibility,28 connects phosphatidyl inositol 3 phosphate (PIP3) and phosphotyrosine signalling and the Arf and Rho signalling pathways.29 Here, CDKN2A is linked to type 2 diabetes mellitus.