YY2 and skin neoplasm: Furthermore, two types of YY2 somatic mutations K244Q and S246F (lysine 244 to glutamine and serine 246 to phenylalanine) identified in colon and skin cancer, respectively, could also decrease the methylation of YY2 at K247 and subsequently attenuated the YY2 DNA‐binding affinity to the promoter of its target genes.23