OLR1 could activate the OLR1/c‐Myc/HMGA2 axis and promote the metastatic potential of pancreatic cancer cells,53 while PDE2A could promote the growth and invasiveness of malignant melanoma cells via cAMP‐PDE signalling pathway,54 and PTGS2 could activate the PI3K/AKT/NF‐kB signalling pathway, leading to the increase of the osteosarcoma cell migration potential.55 Here, OLR1 is linked to osteosarcoma.