During inflammation, LPA is majorly generated in activated platelets through the degradation of lysophosphatidylcholine by secretory lysophospholipase D termed as autotaxin (ATX) that is detected to be highly elevated in the activated arthritic synovial fluid from RA patients and AIA rats,77, 78 and berberine has been indicated to decrease the expression of ATX in RAFLS cells and thus decrease LPA levels in RA condition.77 Here, ENPP2 is linked to rheumatoid arthritis.