Multiple signalling pathways including cell cycle arresting signalling, apoptosis‐mediating pathways, PI3K/Akt, Wnt1/β‐catenin, AMPK/lipogenesis and LPA/LPA1/ERK/p38 MAPK, CST and BUT are the common molecular targets of berberine in RA disorder, which can be considered as the efficient therapeutic target for managing RA. This evidence concerns the gene WNT1 and rheumatoid arthritis.