Furthermore, five pathways were over-represented: the thyrotropin-releasing hormone receptor (TSHR) signalling pathway, oxytocin receptor (OXTR) mediated signalling pathway, Alzheimer’s disease amyloid secretase pathway, serotonin receptor (5HT2R) signalling pathway, and heterotrimeric G-protein signalling pathway-Gq alpha and Go alpha mediated pathway (Table 1). This evidence concerns the gene TRHR and early-onset autosomal dominant Alzheimer disease.