One is malabsorption secondary to osmotic diarrhea that is induced by enterocyte damage, death, or epithelial absorption degradation, and the other is secretory diarrhea caused by nonstructural proteins, such as NSP4.10 In addition, 5-HT secretion mediated by rotavirus infection may activate signaling pathways that give rise to diarrhea and emesis, and it is also involved in the onset of diarrhea and emesis among pediatric patients.11 This evidence concerns the gene PRSS57 and Rotavirus infection.