Some studies found that in patients with hyperuricemia, the accumulation of uric acid and activation of xanthine oxidoreductase may induce inflammation and increase oxidative stress, accelerates atherosclerotic progression, and promote the progression of PAD.13 In a study of 508 patients with T2DM, Tseng found uric acid levels were higher in patients with PAD than in those without, suggesting elevated uric acid level is a significant and independent risk factor for PAD in patients with T2DM.9 In Tseng’s study, some patients were not elderly, while they obtained the same conclusion. Here, XDH is linked to type 2 diabetes mellitus.