The results of univariate analysis revealed the two groups significantly differed in age (p=0.003), course of T2DM (p=0.001), hypertension (p=0.006), smoking habits (p<0.001), alcohol use (p<0.001), hyperuricemia (p<0.01), hs-CRP (p<0.01), white cell count (p<0.001), lymphocyte count (p<0.001) and diabetic neuropathy (p<0.001), but did not in gender (p=0.19), BMI (p=0.29), HbA1c (p=0.069), hyperlipidemia (p=0.28), and diabetic retinopathy (p=0.67)(Fig. 1, 2). This evidence concerns the gene CRP and diabetic retinopathy.