Osteoprotegerin levels are elevated as a compensatory response to halt the bone loss which is common in CLD.6 A recent research shows, that there is up-regulation of gene expression of these members of TNF superfamily in serum of patients with jaundice that results in elevation of serum osteoprotegerin in patients of chronic liver disease.7 The gene discussed is TNFRSF11B; the disease is Jaundice.