The binary logistic regression analysis showed that in CLD cases, there was a positive association of OPG with splenomegaly (OR = 2.10, p = 0.009), hepatomegaly (OR = 4.41, p = 0.012), skin pigmentation (OR = 2.06, p = 0.028), malena (OR = 1.87, p = 0.018), and prolong bleeding (OR = 1.86, p = 0.023). The gene discussed is TNFRSF11B; the disease is congenital secretory chloride diarrhea 1.