TNFRSF11B and congenital secretory chloride diarrhea 1: Osteoprotegerin levels are elevated as a compensatory response to halt the bone loss which is common in CLD.6 A recent research shows, that there is up-regulation of gene expression of these members of TNF superfamily in serum of patients with jaundice that results in elevation of serum osteoprotegerin in patients of chronic liver disease.7