TGFB1 and hepatitis B virus infection: In line with our results, one study found an increase level of OPG in Child-Pugh classification C as compare to A. In their study, they took 30 cirrohotic patients and serological markers were positive for hepatitis B and C. OPG levels in Child–Pugh A patients was 5.1 pmol/l; range 4.8–5.2 which were significantly lower than those of patients in Group C 6.5 pmol/l; range 4.8–8.4).14 The reason for this increase in OPG levels in cirrhotic liver was linked to TGFβ.