Gender- specific 99th percentile URL variations in cTrop concentration have also been recognized more and more.14 Adnan et al suggested the role of cardiac troponin I elevation in the MI diagnosis.15 Several studies have shown the manufacture’s 99th percentile URL does not match values seen in large community- based cohort studies and may result in major differences in the determination of the 99th percentile URL. The gene discussed is TNNI3; the disease is myocardial infarction.