GRIN1 and psychotic disorder: Dependent on the circumstances, i.e., absence or presence of an underlying brain inflammation, NMDAR1-AB or other brain-directed AB in higher amounts may contribute to more chronic processes (dementia, psychosis, epilepsy) or fulminant courses (“anti-NMDAR encephalitis”), provided access to the brain upon BBB dysfunction or intrathecal synthesis by respective B cell clones in presence or even absence of specific T cells.